Process of preparing organic iron compounds.



UNITED STATES PATENT OFETQE...

JOSEPH L. TURNER, OF PHILADELPHIA, PENNSYLVANIA, i lND CHARLES E.VANDERKLEED,

OF COLLINGSWOOD, NEW JERSEY, ASSIGNORS TO H. K. MULFORD COMPANY, OFPHILA- DELPHIA, PENNSYLVANIA, A CORPORATION OF PENNSYLVANIA.

PROCESS OF PREPARING ORGANIC IRON COMPOUNDS.

Specification of Letters Patent.-

Patented Dec. 8, 1908.

Application filed July 15, 1907. Serial No. 383,869.

To all whom it may concern:

Be it known that we. JOSEPH L. Truman, a subject of the Czar of Russia,and CHARLES E. VANDERKLEED, a citizen of the United States, residing,respectively, in Philadelphia, Pennsylvania, and Collingswood, NewJersey, have invented certain Improvements in Processes of PreparingOrganic Iron Oompounds, of which the following is a specification.

One object of our invention is to provide a solve in a Weak alkali. theproduct resultingfrom the action of iron salts, such as soluble irontartrate or citrate, upon a solution of a nucleo-proteid or an albumen,and then free the solution from any excess of alkali by dialyzingthrough a suitable membrane. The solution is finally treated withpancreatic juice.

As a typical example of the proportions employed in carrying out ourinvention, we dissolve 100 lbs. of the product obtained by the action of110-pounds of iron and potassium tartrate on 110-pounds of casein in asolution of 10 lbs. of sodium hydroxid dis solved in 100 gals. of water.The solution is at once dialyzed against pure water to free it from theuncombined alkali, and upon the completion of the dialyzation, thesolution is brought to a temperature of 98-99 F. 5 lbs. of pancreaticferment (Pancreatin U. S. P.) or 350 grains for each gallon of solutionare added in order to digest the compound in such a manner as to permitof its ready absorption inthe intestines and the whole kept at the abovenoted temperature for about an hour. The resulting compound is thenbrought to the boiling point, cooled, and finally filtered.

The filtrate can be either dried in cacao and the resulting compoundscaled or powdered. or it may be used in the form of a. solution withthe aid of the necessary preservatives such as alcohol or the like.

It is to be. understood that cg albumen is the equivalent of and may besubstituted for the casein in carrying out our invention and that theproportions noted may be considerably varied Without departing from saidinvention.

We claim as our invention 1. The process of preparing organic ironcompounds which consists in dissolving an iron nucleo-proteid in asolution of an alkali, subjecting the resulting solution to dialysisagainst water, and reacting upon the resulting liquid with pancreaticferment.

. 2. The process of preparing organic iron compound which consists indissolving 100 lbs. of an iron nuclco-proteid compound in 100 gals. ofwater containing 10 lbs. of sodium hydroxid in solution, dialyzing theresulting compoundagainst pure Water and heating the dialyzed solutionwith 5 lbs. of pancreatic ferment at a temperature of 98-99 F.,substantially as described.

3. The process of preparing organic iron compound which consists in(llSSOlVlII in sodium hydroxid a product resulting -om the action ofsolubleiron tartrate on a nu cleo-proteid, dialyzing. the solutionagainst pure water, and then reacting upon the so lution with pancreaticferment.

In testimony whereof we have signed our names to this specification, inthe presence of two subscribing witnesses.

\Vitnesses:

WILLIAM E. BRADLEY, J 0s. H. KLEIN.

